287111

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1856770..1857272 Replicon chromosome
Accession NZ_LR134220
Organism Escherichia coli strain NCTC11121

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL088_RS08945 Protein ID WP_000767829.1
Coordinates 1857018..1857272 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL088_RS08940 Protein ID WP_001259255.1
Coordinates 1856770..1857021 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL088_RS08915 1851949..1853016 - 1068 WP_000080088.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL088_RS08920 1853016..1854086 - 1071 WP_000108969.1 histidinol-phosphate transaminase -
EL088_RS08925 1854083..1855387 - 1305 WP_021823828.1 histidinol dehydrogenase -
EL088_RS08930 1855393..1856292 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL088_RS08935 1856438..1856488 - 51 WP_001364200.1 his operon leader peptide -
EL088_RS08940 1856770..1857021 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL088_RS08945 1857018..1857272 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL088_RS08950 1857355..1858179 + 825 WP_000754763.1 SDR family oxidoreductase -
EL088_RS08955 1858225..1859154 + 930 WP_097729089.1 LysR family transcriptional regulator -
EL088_RS08960 1859369..1859431 + 63 WP_010723108.1 membrane protein YoeI -
EL088_RS08965 1859421..1860779 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL088_RS08970 1860958..1862016 + 1059 WP_000492305.1 transport protein YeeE -
EL088_RS08975 1862030..1862257 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287111 WP_000767829.1 NZ_LR134220:1857018-1857272 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287111 WP_001259255.1 NZ_LR134220:1856770-1857021 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References