Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1856770..1857272 Replicon chromosome
Accession NZ_LR134220
Organism Escherichia coli strain NCTC11121

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL088_RS08945 Protein ID WP_000767829.1
Coordinates 1857018..1857272 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL088_RS08940 Protein ID WP_001259255.1
Coordinates 1856770..1857021 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL088_RS08915 1851949..1853016 - 1068 WP_000080088.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL088_RS08920 1853016..1854086 - 1071 WP_000108969.1 histidinol-phosphate transaminase -
EL088_RS08925 1854083..1855387 - 1305 WP_021823828.1 histidinol dehydrogenase -
EL088_RS08930 1855393..1856292 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL088_RS08935 1856438..1856488 - 51 WP_001364200.1 his operon leader peptide -
EL088_RS08940 1856770..1857021 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL088_RS08945 1857018..1857272 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL088_RS08950 1857355..1858179 + 825 WP_000754763.1 SDR family oxidoreductase -
EL088_RS08955 1858225..1859154 + 930 WP_097729089.1 LysR family transcriptional regulator -
EL088_RS08960 1859369..1859431 + 63 WP_010723108.1 membrane protein YoeI -
EL088_RS08965 1859421..1860779 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL088_RS08970 1860958..1862016 + 1059 WP_000492305.1 transport protein YeeE -
EL088_RS08975 1862030..1862257 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287111 WP_000767829.1 NZ_LR134220:1857018-1857272 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287111 WP_001259255.1 NZ_LR134220:1856770-1857021 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References