Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3145950..3146599 Replicon chromosome
Accession NZ_LR134215
Organism Shimwellia blattae strain NCTC12127

Toxin (Protein)


Gene name higB Uniprot ID I2BC85
Locus tag EL083_RS15205 Protein ID WP_002442770.1
Coordinates 3145950..3146303 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID I2BC86
Locus tag EL083_RS15210 Protein ID WP_002442768.1
Coordinates 3146300..3146599 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL083_RS15185 3141580..3142305 - 726 WP_002442777.1 type I-E CRISPR-associated protein Cas5/CasD -
EL083_RS15190 3142315..3143370 - 1056 WP_002442774.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
EL083_RS15195 3143393..3143995 - 603 WP_002442773.1 type I-E CRISPR-associated protein Cse2/CasB -
EL083_RS15200 3143982..3145553 - 1572 WP_002442771.1 type I-E CRISPR-associated protein Cse1/CasA -
EL083_RS15205 3145950..3146303 + 354 WP_002442770.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL083_RS15210 3146300..3146599 + 300 WP_002442768.1 XRE family transcriptional regulator Antitoxin
EL083_RS15215 3146640..3149366 + 2727 WP_002442766.1 CRISPR-associated helicase/endonuclease Cas3 -
EL083_RS15220 3149387..3150568 - 1182 WP_014716151.1 cystathionine beta-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13602.53 Da        Isoelectric Point: 8.7754

>T287086 WP_002442770.1 NZ_LR134215:3145950-3146303 [Shimwellia blattae]
MWTVFFGPVFDAWFEEQEPALKEKVLANLRNLEKYGPSLSRPYADTVYGSRYKNMKELRIQYSGYPVRAFFAFDPVRRAI
VLCAGDKSNDKKFYDRMIRIADDEFSAHLATLEGSTK

Download         Length: 354 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11108.98 Da        Isoelectric Point: 5.8787

>AT287086 WP_002442768.1 NZ_LR134215:3146300-3146599 [Shimwellia blattae]
MRTLKEVIAAQTPESQARINEMAEEMILETGLQMMREELQLSQKAVADAMGIRQPAITQIEQRGNDIKLATLKRYIEAMG
GKLSLDVELPTGKRIAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2BC85

Antitoxin

Source ID Structure
AlphaFold DB I2BC86

References