Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 55751..56365 Replicon chromosome
Accession NZ_LR134215
Organism Shimwellia blattae strain NCTC12127

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL083_RS00240 Protein ID WP_002440780.1
Coordinates 56144..56365 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL083_RS00235 Protein ID WP_002440781.1
Coordinates 55751..56086 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL083_RS00225 53402..53860 + 459 WP_002440783.1 transcriptional regulator ArgR -
EL083_RS00230 54119..55468 - 1350 WP_002440782.1 cadaverine/lysine antiporter -
EL083_RS00235 55751..56086 - 336 WP_002440781.1 HigA family addiction module antidote protein Antitoxin
EL083_RS00240 56144..56365 - 222 WP_002440780.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL083_RS00245 56440..57333 - 894 WP_002440779.1 hypothetical protein -
EL083_RS00250 57734..58312 - 579 WP_071840820.1 substrate binding domain-containing protein -
EL083_RS00255 58780..60459 + 1680 WP_014715709.1 sulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-71)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8596.82 Da        Isoelectric Point: 8.8080

>T287069 WP_002440780.1 NZ_LR134215:c56365-56144 [Shimwellia blattae]
VHYCIHTTLARKLDIINAAVTYLDLRSPPGNRYEELNGKLEGYSSIRINQQYRLIFKWVNGKAEDLYLDPHKY

Download         Length: 222 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12681.62 Da        Isoelectric Point: 7.2033

>AT287069 WP_002440781.1 NZ_LR134215:c56086-55751 [Shimwellia blattae]
MKQATRKPTTVGDILLYEYLEPLDLKINELAQMLHVHRNSVSALVNNNRKLTTDMAFRLAKAFDTSVDFWLNLQAAVDLW
EVENDPRAQEELSRIVPVARFIASKADKKIA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References