287065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2368671..2369233 Replicon chromosome
Accession NZ_LR134214
Organism Citrobacter portucalensis strain NCTC11104

Toxin (Protein)


Gene name higB Uniprot ID A0A1C0NXV4
Locus tag EL073_RS11720 Protein ID WP_003833016.1
Coordinates 2368955..2369233 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6H3AUF8
Locus tag EL073_RS11715 Protein ID WP_003833018.1
Coordinates 2368671..2368955 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL073_RS11700 2366366..2367250 + 885 WP_003833024.1 formate dehydrogenase N subunit beta -
EL073_RS11705 2367243..2367899 + 657 WP_003020054.1 formate dehydrogenase-N subunit gamma -
EL073_RS11710 2368029..2368631 + 603 WP_003833020.1 inorganic diphosphatase -
EL073_RS11715 2368671..2368955 - 285 WP_003833018.1 HigA family addiction module antidote protein Antitoxin
EL073_RS11720 2368955..2369233 - 279 WP_003833016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL073_RS11725 2369454..2371169 - 1716 WP_126318076.1 ATP-binding cassette domain-containing protein -
EL073_RS11730 2371479..2373176 - 1698 WP_003833011.1 malate dehydrogenase -
EL073_RS11735 2373356..2373496 - 141 WP_003833009.1 stationary-phase-induced ribosome-associated protein -
EL073_RS11740 2373724..2374155 + 432 WP_003833007.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10667.30 Da        Isoelectric Point: 9.8965

>T287065 WP_003833016.1 NZ_LR134214:c2369233-2368955 [Citrobacter portucalensis]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGERDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.10 Da        Isoelectric Point: 8.8094

>AT287065 WP_003833018.1 NZ_LR134214:c2368955-2368671 [Citrobacter portucalensis]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAEAQ
KSVDISRLRKLAVQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0NXV4

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AUF8

References