Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3787098..3787639 Replicon chromosome
Accession NZ_LR134209
Organism Escherichia coli strain NCTC11476

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag EL080_RS18490 Protein ID WP_000615976.1
Coordinates 3787361..3787639 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag EL080_RS18485 Protein ID WP_000729704.1
Coordinates 3787098..3787358 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL080_RS18460 3782134..3783273 + 1140 WP_032216948.1 flagellar type III secretion system protein FlhB -
EL080_RS18465 3783257..3785350 + 2094 WP_047658924.1 flagellar biosynthesis protein FlhA -
EL080_RS18470 3785455..3785733 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
EL080_RS18475 3785726..3786082 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
EL080_RS18480 3786139..3786912 - 774 WP_000543899.1 C40 family peptidase -
EL080_RS18485 3787098..3787358 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL080_RS18490 3787361..3787639 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL080_RS18495 3787795..3788535 + 741 WP_001225679.1 murein L,D-transpeptidase -
EL080_RS18500 3788506..3789273 - 768 WP_000333380.1 class II glutamine amidotransferase -
EL080_RS18505 3789479..3790057 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T287042 WP_000615976.1 NZ_LR134209:3787361-3787639 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT287042 WP_000729704.1 NZ_LR134209:3787098-3787358 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References