Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 603620..604419 Replicon chromosome
Accession NZ_LR134209
Organism Escherichia coli strain NCTC11476

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag EL080_RS03000 Protein ID WP_000347267.1
Coordinates 603620..604084 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag EL080_RS03005 Protein ID WP_001307405.1
Coordinates 604084..604419 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL080_RS02970 598621..599055 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EL080_RS02975 599073..599951 - 879 WP_001380079.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EL080_RS02980 599941..600720 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EL080_RS02985 600731..601204 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EL080_RS02990 601227..602507 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
EL080_RS02995 602756..603565 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EL080_RS03000 603620..604084 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EL080_RS03005 604084..604419 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EL080_RS03010 604568..606139 - 1572 WP_001273741.1 galactarate dehydratase -
EL080_RS03015 606514..607848 + 1335 WP_126316187.1 galactarate/glucarate/glycerate transporter GarP -
EL080_RS03020 607864..608634 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T287031 WP_000347267.1 NZ_LR134209:c604084-603620 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT287031 WP_001307405.1 NZ_LR134209:c604419-604084 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References