Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1580232..1580893 Replicon chromosome
Accession NZ_LR134201
Organism Cedecea lapagei strain NCTC11466

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL098_RS07635 Protein ID WP_126355688.1
Coordinates 1580232..1580606 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL098_RS07640 Protein ID WP_126355689.1
Coordinates 1580591..1580893 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL098_RS07615 1575806..1576864 + 1059 WP_126355685.1 FUSC family protein -
EL098_RS07620 1577038..1577373 + 336 WP_008455006.1 DUF496 family protein -
EL098_RS07625 1577415..1577723 - 309 WP_126355686.1 helix-turn-helix domain-containing protein -
EL098_RS07630 1577916..1580018 + 2103 WP_126355687.1 elongation factor G -
EL098_RS07635 1580232..1580606 + 375 WP_126355688.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL098_RS07640 1580591..1580893 + 303 WP_126355689.1 XRE family transcriptional regulator Antitoxin
EL098_RS07645 1580927..1581301 - 375 WP_126355690.1 DUF4440 domain-containing protein -
EL098_RS07650 1581305..1582681 - 1377 WP_126355691.1 MFS transporter -
EL098_RS07655 1582792..1583691 + 900 WP_126355692.1 LysR family transcriptional regulator -
EL098_RS07660 1583708..1585234 - 1527 WP_126355693.1 cytosine permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14341.61 Da        Isoelectric Point: 8.6997

>T287018 WP_126355688.1 NZ_LR134201:1580232-1580606 [Cedecea lapagei]
MWSIKMTDTFDAWFTASDDATKACVIASMVLLKSRGPLLSRPYADTVRGSQYANMKELRVQCKGEPLRLFFAFDIRRYAI
LLCAGNKVGNEKRFYDLMIPRADKEFAAHLKQLTEKEQTEWVEH

Download         Length: 375 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11110.97 Da        Isoelectric Point: 7.2052

>AT287018 WP_126355689.1 NZ_LR134201:1580591-1580893 [Cedecea lapagei]
MGRTLEQLLAEEKPEVVAAAQAMADEMLLNIHLAELRDKVRKTQNEMAQKLGVKQPTVAEMEKKGRDIKLSSLKRYVEAA
GGKVKLDIELPDGTHFNIAL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References