Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1135948..1136675 Replicon chromosome
Accession NZ_LR134201
Organism Cedecea lapagei strain NCTC11466

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL098_RS05600 Protein ID WP_126355364.1
Coordinates 1135948..1136259 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL098_RS05605 Protein ID WP_126355365.1
Coordinates 1136256..1136675 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL098_RS05585 1131129..1132781 - 1653 WP_126355361.1 hypothetical protein -
EL098_RS05590 1133368..1134576 + 1209 WP_126355362.1 MFS transporter -
EL098_RS05595 1134566..1135663 - 1098 WP_126355363.1 tRNA 2-selenouridine(34) synthase MnmH -
EL098_RS05600 1135948..1136259 + 312 WP_126355364.1 type II toxin-antitoxin system HigB family toxin Toxin
EL098_RS05605 1136256..1136675 + 420 WP_126355365.1 helix-turn-helix domain-containing protein Antitoxin
EL098_RS05610 1136818..1137888 - 1071 WP_126355366.1 5-(carboxyamino)imidazole ribonucleotide synthase -
EL098_RS05615 1137885..1138394 - 510 WP_038480306.1 5-(carboxyamino)imidazole ribonucleotide mutase -
EL098_RS05620 1138533..1139255 - 723 WP_126355367.1 UDP-2,3-diacylglucosamine diphosphatase -
EL098_RS05625 1139255..1139749 - 495 WP_126355368.1 peptidylprolyl isomerase B -
EL098_RS05630 1139925..1141310 + 1386 WP_126355369.1 cysteine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12309.01 Da        Isoelectric Point: 9.9081

>T287017 WP_126355364.1 NZ_LR134201:1135948-1136259 [Cedecea lapagei]
MHVVSRAPFDTATRQFPNHAAALDDVYRTLKAENYTSPDEMKKRFASLDRMKYREKWWVINVGGGNLRVMFFADFERGKI
FIKHITAHDEYDKLTDFYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15528.73 Da        Isoelectric Point: 4.4867

>AT287017 WP_126355365.1 NZ_LR134201:1136256-1136675 [Cedecea lapagei]
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLIEHEPDHPLVEMLVAKIAQYEDEAEEFAEFNDRIAALPGGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLEHMKALARRFNIPPSSFLDA

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References