Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2545669..2546192 Replicon chromosome
Accession NZ_LR134193
Organism Staphylococcus aureus strain NCTC13616

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EL036_RS13160 Protein ID WP_000074048.1
Coordinates 2545669..2545935 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EL036_RS13165 Protein ID WP_000587616.1
Coordinates 2545935..2546192 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL036_RS13140 2540880..2542067 - 1188 WP_000026196.1 MFS transporter -
EL036_RS13145 2542461..2543237 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
EL036_RS13150 2543230..2543892 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
EL036_RS13155 2544238..2545314 - 1077 WP_001076688.1 M42 family metallopeptidase -
EL036_RS13160 2545669..2545935 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EL036_RS13165 2545935..2546192 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL036_RS13175 2546551..2547006 + 456 WP_000732088.1 DUF1307 domain-containing protein -
EL036_RS13180 2547174..2548751 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
EL036_RS13185 2548946..2549695 + 750 WP_000072439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286990 WP_000074048.1 NZ_LR134193:c2545935-2545669 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286990 WP_000587616.1 NZ_LR134193:c2546192-2545935 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References