Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2487661..2488178 Replicon chromosome
Accession NZ_LR134193
Organism Staphylococcus aureus strain NCTC13616

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EL036_RS12855 Protein ID WP_000113261.1
Coordinates 2487661..2487927 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EL036_RS12860 Protein ID WP_000584499.1
Coordinates 2487927..2488178 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL036_RS12830 2483096..2483632 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
EL036_RS12835 2483867..2484691 - 825 WP_000594637.1 formate/nitrite transporter family protein -
EL036_RS12840 2484898..2485077 - 180 WP_126497605.1 hypothetical protein -
EL036_RS12845 2485164..2485631 - 468 WP_000153345.1 SRPBCC domain-containing protein -
EL036_RS12850 2485817..2487367 - 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EL036_RS12855 2487661..2487927 - 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
EL036_RS12860 2487927..2488178 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL036_RS12865 2488341..2488442 - 102 Protein_2400 hypothetical protein -
EL036_RS12870 2488449..2489048 - 600 WP_000162810.1 DsbA family protein -
EL036_RS12875 2489067..2489429 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EL036_RS12880 2489684..2490934 + 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
EL036_RS12885 2491019..2491750 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
EL036_RS12890 2491747..2492466 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T286988 WP_000113261.1 NZ_LR134193:c2487927-2487661 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286988 WP_000584499.1 NZ_LR134193:c2488178-2487927 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References