Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF2/-
Location 2048014..2048313 Replicon chromosome
Accession NZ_LR134193
Organism Staphylococcus aureus strain NCTC13616

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag EL036_RS10415 Protein ID WP_011447039.1
Coordinates 2048137..2048313 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2048014..2048069 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL036_RS10370 2043345..2043605 + 261 WP_001791826.1 hypothetical protein -
EL036_RS10375 2043658..2044008 - 351 WP_000702263.1 complement inhibitor SCIN-A -
EL036_RS10380 2044693..2045142 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
EL036_RS10385 2045237..2045572 - 336 Protein_1932 SH3 domain-containing protein -
EL036_RS10395 2046222..2046713 - 492 WP_000919349.1 staphylokinase -
EL036_RS10400 2046904..2047659 - 756 WP_000861039.1 CHAP domain-containing protein -
EL036_RS10405 2047671..2047925 - 255 WP_000611512.1 phage holin -
EL036_RS10410 2047977..2048084 + 108 WP_001791821.1 hypothetical protein -
- 2048006..2048145 + 140 NuclAT_1 - -
- 2048006..2048145 + 140 NuclAT_1 - -
- 2048006..2048145 + 140 NuclAT_1 - -
- 2048006..2048145 + 140 NuclAT_1 - -
- 2048014..2048069 + 56 - - Antitoxin
EL036_RS10415 2048137..2048313 - 177 WP_011447039.1 putative holin-like toxin Toxin
EL036_RS10420 2048463..2048759 - 297 WP_000539688.1 DUF2951 domain-containing protein -
EL036_RS10425 2048817..2049104 - 288 WP_001040261.1 hypothetical protein -
EL036_RS10430 2049151..2049303 - 153 WP_001153681.1 hypothetical protein -
EL036_RS10435 2049293..2053078 - 3786 WP_000582168.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2043658..2101579 57921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T286983 WP_011447039.1 NZ_LR134193:c2048313-2048137 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT286983 NZ_LR134193:2048014-2048069 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References