Detailed information of TA system TA286982

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2048006..2048313
• Replicon: chromosome
• Accession: NZ_LR134193
• Organism: Staphylococcus aureus strain NCTC13616

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EL036_RS10415
• Protein ID: WP_011447039.1
• Coordinates: 2048137..2048313 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2048006..2048145 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL036_RS10370	2043345..2043605	+	261	WP_001791826.1	hypothetical protein	-
EL036_RS10375	2043658..2044008	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
EL036_RS10380	2044693..2045142	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
EL036_RS10385	2045237..2045572	-	336	Protein_1932	SH3 domain-containing protein	-
EL036_RS10395	2046222..2046713	-	492	WP_000919349.1	staphylokinase	-
EL036_RS10400	2046904..2047659	-	756	WP_000861039.1	CHAP domain-containing protein	-
EL036_RS10405	2047671..2047925	-	255	WP_000611512.1	phage holin	-
EL036_RS10410	2047977..2048084	+	108	WP_001791821.1	hypothetical protein	-
-	2048006..2048145	+	140	NuclAT_1	-	Antitoxin
-	2048006..2048145	+	140	NuclAT_1	-	Antitoxin
-	2048006..2048145	+	140	NuclAT_1	-	Antitoxin
-	2048006..2048145	+	140	NuclAT_1	-	Antitoxin
EL036_RS10415	2048137..2048313	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EL036_RS10420	2048463..2048759	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
EL036_RS10425	2048817..2049104	-	288	WP_001040261.1	hypothetical protein	-
EL036_RS10430	2049151..2049303	-	153	WP_001153681.1	hypothetical protein	-
EL036_RS10435	2049293..2053078	-	3786	WP_000582168.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2043658..2101579	57921

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T286982 WP_011447039.1 NZ_LR134193:c2048313-2048137 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT286982 NZ_LR134193:2048006-2048145 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin