286970

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1779303..1780632 Replicon chromosome
Accession NZ_LR134189
Organism Providencia rustigianii strain NCTC6933

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL059_RS08245 Protein ID WP_115164270.1
Coordinates 1779303..1780325 (-) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID D1NZB1
Locus tag EL059_RS08250 Protein ID WP_006813160.1
Coordinates 1780318..1780632 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL059_RS08225 1775203..1776714 + 1512 WP_115164269.1 alanine:cation symporter family protein -
EL059_RS08235 1777162..1778103 + 942 WP_112836678.1 glyoxylate/hydroxypyruvate reductase GhrA -
EL059_RS08240 1778673..1779227 + 555 WP_006813162.1 molecular chaperone -
EL059_RS08245 1779303..1780325 - 1023 WP_115164270.1 HipA domain-containing protein Toxin
EL059_RS08250 1780318..1780632 - 315 WP_006813160.1 HipA N-terminal domain-containing protein Antitoxin
EL059_RS08255 1780617..1780862 - 246 WP_006813159.1 hypothetical protein -
EL059_RS08260 1781115..1781675 - 561 WP_006813158.1 lipoprotein -
EL059_RS08265 1781715..1782920 - 1206 WP_126436780.1 multidrug efflux MFS transporter MdtH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-301)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38536.31 Da        Isoelectric Point: 6.7648

>T286970 WP_115164270.1 NZ_LR134189:c1780325-1779303 [Providencia rustigianii]
MNEKHCLINLKKLNNEELEFGYSQAGINELFGKNSLTLELPFTRSQFIQDQPANQTGMSISGFQPKLSLRLENGSLYVAN
NKGTFILKPSPEAYPFLAENEHATMTVMKRLKFPTPPFGLIPFQSSLDKPKEFAFIIQRYDRLGNDVQKLHQEQLDGAMG
INDKYGNVDGTKSVSYEKAAKFIIENVDDSLASKRDLFLRIIYAYVLGNNDYHLRNISILLPQNKKPSLAPIYDFVSIVP
YPSVFTEYLALPLLELEENDSDIAPGLNSQYGEYTGADFILLAQGIGIRNELAKKLLLRVIKSHQLITDTYTESHLPDVD
KLAIIKYISRRMTLLGIMRF

Download         Length: 1023 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11960.63 Da        Isoelectric Point: 5.0746

>AT286970 WP_006813160.1 NZ_LR134189:c1780632-1780318 [Providencia rustigianii]
MSRKVEVWLYNIPVGILAEVTNGYSFQYYQHYDGQSVSLSMGVRSEPYLCDELHPFFKGLAPEGWLKKRYSELQKIDPND
LFGMLIQNGNDLLGAITFKEIAHE

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A379G3C9

References