Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1529243..1529968 Replicon chromosome
Accession NZ_LR134189
Organism Providencia rustigianii strain NCTC6933

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL059_RS06985 Protein ID WP_115164162.1
Coordinates 1529663..1529968 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL059_RS06980 Protein ID WP_006813416.1
Coordinates 1529243..1529659 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL059_RS06965 1525330..1526307 + 978 WP_006813419.1 flagellar assembly peptidoglycan hydrolase FlgJ -
EL059_RS06970 1526446..1528090 + 1645 Protein_1344 flagellar hook-associated protein FlgK -
EL059_RS06975 1528139..1529074 + 936 WP_039854240.1 flagellar hook-associated protein FlgL -
EL059_RS06980 1529243..1529659 - 417 WP_006813416.1 helix-turn-helix domain-containing protein Antitoxin
EL059_RS06985 1529663..1529968 - 306 WP_115164162.1 type II toxin-antitoxin system HigB family toxin Toxin
EL059_RS06990 1530289..1531069 - 781 Protein_1348 flagellar type III secretion system protein FliR -
EL059_RS06995 1531072..1531341 - 270 WP_006813413.1 flagellar biosynthesis protein FliQ -
EL059_RS07000 1531350..1532093 - 744 WP_006813412.1 flagellar type III secretion system pore protein FliP -
EL059_RS07005 1532106..1532582 - 477 WP_006813411.1 flagellar biosynthetic protein FliO -
EL059_RS07010 1532584..1533000 - 417 Protein_1352 flagellar motor switch protein FliN -
EL059_RS07015 1532993..1534000 - 1008 WP_115164172.1 flagellar motor switch protein FliM -
EL059_RS07020 1534006..1534488 - 483 WP_006813408.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12062.00 Da        Isoelectric Point: 10.4596

>T286969 WP_115164162.1 NZ_LR134189:c1529968-1529663 [Providencia rustigianii]
MHVISREPFVHASERNPKHAKALLDVYKTLKQGSYSSPDELKNIFPSLDRMKYREKWWVIDVGGNALRILFFADFKKSKI
FIKHISTHAEYNKLMNYYRRT

Download         Length: 306 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 16096.38 Da        Isoelectric Point: 5.2536

>AT286969 WP_006813416.1 NZ_LR134189:c1529659-1529243 [Providencia rustigianii]
MIFSEAIQTANHLIHLIPILGKNHSRRDYEDAIKLVEYLVEYDPDNPLVEILCEKIDHYEDNAPEFADFNRKLKQCDDAV
AVLRTLMDQYNLNTTDFANEIGSRSYVSRILNGERNLSLEHMKKLAERFKLPVTIFIK

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References