Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 615974..616663 Replicon chromosome
Accession NZ_LR134189
Organism Providencia rustigianii strain NCTC6933

Toxin (Protein)


Gene name higB Uniprot ID D1P6V8
Locus tag EL059_RS02800 Protein ID WP_006815972.1
Coordinates 615974..616294 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL059_RS02805 Protein ID WP_039855724.1
Coordinates 616331..616663 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL059_RS02785 611206..612219 + 1014 WP_006815975.1 mechanosensitive ion channel family protein -
EL059_RS02790 612492..614651 + 2160 WP_126436334.1 ornithine decarboxylase -
EL059_RS02795 614751..615686 + 936 WP_006815973.1 nucleoside hydrolase -
EL059_RS02800 615974..616294 + 321 WP_006815972.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL059_RS02805 616331..616663 + 333 WP_039855724.1 HigA family addiction module antidote protein Antitoxin
EL059_RS02810 616776..617801 + 1026 WP_112836104.1 tRNA dihydrouridine(20/20a) synthase DusA -
EL059_RS18375 617903..618076 + 174 WP_006815969.1 hypothetical protein -
EL059_RS02815 618122..619105 - 984 WP_126436336.1 quinone oxidoreductase -
EL059_RS02820 619315..620724 + 1410 WP_006815966.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12700.77 Da        Isoelectric Point: 8.4429

>T286965 WP_006815972.1 NZ_LR134189:615974-616294 [Providencia rustigianii]
MEEVYVNEDNDCRLIFRDEYLRLFYVYGKLHRLIPSIICTVLARKLDMLNAAKTLQDFKSPPGNRFKQLKPPLEEFYSIR
VNGQYRLIFKWKDTVEGLYLDPHKDV

Download         Length: 321 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12698.66 Da        Isoelectric Point: 7.4004

>AT286965 WP_039855724.1 NZ_LR134189:616331-616663 [Providencia rustigianii]
MMQATRKPASVGDILLYEYLLPTGMKIHELAELLGVHRNTVSSLINNNRKLSTDMAFKLAKAFGTSKQFWINLQQALDIW
EVENDPRLQEEISHILHYEDFLKQKSQKVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D1P6V8

Antitoxin

Source ID Structure

References