286963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3363819..3365062 Replicon chromosome
Accession NZ_LR134178
Organism Legionella sainthelensi strain NCTC12450

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL064_RS14665 Protein ID WP_115705424.1
Coordinates 3364124..3365062 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag EL064_RS14660 Protein ID WP_115705422.1
Coordinates 3363819..3364127 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL064_RS14630 3359146..3359859 + 714 WP_128130233.1 hemerythrin domain-containing protein -
EL064_RS14635 3359904..3360432 - 529 Protein_2863 chromate transporter -
EL064_RS14640 3360604..3360819 - 216 WP_115705414.1 hypothetical protein -
EL064_RS14645 3361016..3361276 - 261 WP_128130471.1 hypothetical protein -
EL064_RS14650 3361572..3362429 + 858 WP_115705418.1 universal stress protein -
EL064_RS17790 3362709..3362846 - 138 WP_164838683.1 hypothetical protein -
EL064_RS14655 3363595..3363822 + 228 WP_115705420.1 helix-turn-helix transcriptional regulator -
EL064_RS14660 3363819..3364127 + 309 WP_115705422.1 HipA N-terminal domain-containing protein Antitoxin
EL064_RS14665 3364124..3365062 + 939 WP_115705424.1 lpg2370 family Dot/Icm T4SS effector Toxin
EL064_RS14670 3365151..3365336 - 186 Protein_2871 integrase -
EL064_RS14675 3365757..3367487 + 1731 WP_128130234.1 hypothetical protein -
EL064_RS14680 3367753..3369123 - 1371 WP_115705428.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35946.77 Da        Isoelectric Point: 9.3197

>T286963 WP_115705424.1 NZ_LR134178:3364124-3365062 [Legionella sainthelensi]
MKRCPITYDVISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQKG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLIYSKDNSFTYFIKRFDRIGHNKKLAVEDFAQLSGEDRHTKYKS
SMEKVIAVIAQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKERKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNVTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQIIPKWQELIGSSFLSQLMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11640.52 Da        Isoelectric Point: 4.6017

>AT286963 WP_115705422.1 NZ_LR134178:3363819-3364127 [Legionella sainthelensi]
MRKAYVSVNGIRAGILEELEGKKYQFTYLNDYQGAPVSLTMPLTNKIYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References