286960

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2046128..2047371 Replicon chromosome
Accession NZ_LR134176
Organism Legionella pneumophila strain NCTC12179

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL037_RS09210 Protein ID WP_027265541.1
Coordinates 2046433..2047371 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag EL037_RS09205 Protein ID WP_027265542.1
Coordinates 2046128..2046436 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL037_RS09180 (NCTC12179_01942) 2041635..2042060 + 426 WP_027265547.1 hypothetical protein -
EL037_RS09185 (NCTC12179_01943) 2042323..2042688 - 366 WP_027265546.1 TraK family protein -
EL037_RS09190 (NCTC12179_01945) 2043031..2044797 - 1767 WP_027265545.1 DUF927 domain-containing protein -
EL037_RS09195 (NCTC12179_01946) 2044877..2045131 - 255 WP_027265544.1 helix-turn-helix domain-containing protein -
EL037_RS09200 (NCTC12179_01947) 2045904..2046131 + 228 WP_027265543.1 helix-turn-helix transcriptional regulator -
EL037_RS09205 (NCTC12179_01948) 2046128..2046436 + 309 WP_027265542.1 HipA N-terminal domain-containing protein Antitoxin
EL037_RS09210 (NCTC12179_01949) 2046433..2047371 + 939 WP_027265541.1 lpg2370 family Dot/Icm T4SS effector Toxin
EL037_RS09215 (NCTC12179_01950) 2047644..2048177 + 534 WP_027265540.1 hypothetical protein -
EL037_RS09220 (NCTC12179_01951) 2048174..2049106 + 933 WP_027265539.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
EL037_RS09225 (NCTC12179_01952) 2049158..2050135 - 978 WP_027265538.1 metallophosphoesterase -
EL037_RS09230 (NCTC12179_01953) 2050165..2051178 - 1014 WP_027265537.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
EL037_RS09235 (NCTC12179_01954) 2051171..2051776 - 606 WP_050598115.1 DUF6088 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(4-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36008.88 Da        Isoelectric Point: 9.2986

>T286960 WP_027265541.1 NZ_LR134176:2046433-2047371 [Legionella pneumophila]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIQQFCTFPKIEFVKLFKLTLFNFLIGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGVSFLSQPMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11527.33 Da        Isoelectric Point: 4.4805

>AT286960 WP_027265542.1 NZ_LR134176:2046128-2046436 [Legionella pneumophila]
MRKACVSVDGIKAGTLEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYEFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References