Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1925232..1925882 Replicon chromosome
Accession NZ_LR134169
Organism Actinobacillus lignieresii strain NCTC10568

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ELZ64_RS09230 Protein ID WP_126375324.1
Coordinates 1925541..1925882 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ELZ64_RS09225 Protein ID WP_115587655.1
Coordinates 1925232..1925540 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ64_RS09200 1920384..1920953 - 570 WP_115587652.1 septal ring lytic transglycosylase RlpA family protein -
ELZ64_RS09205 1921128..1922252 - 1125 WP_126375322.1 rod shape-determining protein RodA -
ELZ64_RS09210 1922245..1924205 - 1961 Protein_1784 penicillin-binding protein 2 -
ELZ64_RS09215 1924288..1924755 - 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
ELZ64_RS09220 1924777..1925091 - 315 WP_126375531.1 ribosome silencing factor -
ELZ64_RS09225 1925232..1925540 - 309 WP_115587655.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ELZ64_RS09230 1925541..1925882 - 342 WP_126375324.1 toxin Toxin
ELZ64_RS09235 1926062..1928656 - 2595 WP_126375326.1 DNA mismatch repair protein MutS -
ELZ64_RS09240 1928822..1929571 - 750 WP_115587658.1 amino acid ABC transporter ATP-binding protein -
ELZ64_RS09245 1929593..1930309 - 717 WP_115587659.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13304.20 Da        Isoelectric Point: 9.8649

>T286954 WP_126375324.1 NZ_LR134169:c1925882-1925541 [Actinobacillus lignieresii]
VKLVFVELPPFNKFRYENLTDDDYREFQEYLMNNPEAGDIVQGINGLRKISISTQSRGKKGGARVIYYYYVRGSQIWLFT
GYNKSRKIDLNSMERKAFSKVLEHLKNIADREL

Download         Length: 342 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11650.49 Da        Isoelectric Point: 7.2032

>AT286954 WP_115587655.1 NZ_LR134169:c1925540-1925232 [Actinobacillus lignieresii]
MGRLFDDLMEGAEALEQYLQGKITLRTTVLEKPEPIELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QAVLLLRMVDKSPQLLEQMAQF

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References