Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1583373..1584012 Replicon chromosome
Accession NZ_LR134168
Organism Haemophilus influenzae strain NCTC11394

Toxin (Protein)


Gene name higB Uniprot ID A0A8B2WM63
Locus tag ELZ62_RS08050 Protein ID WP_005694311.1
Coordinates 1583707..1584012 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ELZ62_RS08045 Protein ID WP_005650217.1
Coordinates 1583373..1583696 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ62_RS09390 1579118..1579291 - 174 WP_005652999.1 DUF5363 domain-containing protein -
ELZ62_RS08030 1579288..1581132 - 1845 WP_015702146.1 tRNA(Met) cytidine acetyltransferase TmcA -
ELZ62_RS08035 1581137..1581478 - 342 WP_005666735.1 SirB2 family protein -
ELZ62_RS08040 1581540..1583210 - 1671 WP_015702145.1 energy-dependent translational throttle protein EttA -
ELZ62_RS08045 1583373..1583696 - 324 WP_005650217.1 HigA family addiction module antidote protein Antitoxin
ELZ62_RS08050 1583707..1584012 - 306 WP_005694311.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELZ62_RS08055 1584338..1584958 + 621 WP_005650213.1 zinc transporter binding subunit ZevA -
ELZ62_RS08060 1584961..1585929 + 969 WP_015702144.1 zinc transporter permease subunit ZevB -
ELZ62_RS08070 1586544..1588583 + 2040 WP_005646675.1 excinuclease ABC subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12248.89 Da        Isoelectric Point: 8.0244

>T286950 WP_005694311.1 NZ_LR134168:c1584012-1583707 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYCL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT286950 WP_005650217.1 NZ_LR134168:c1583696-1583373 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B2WM63

Antitoxin

Source ID Structure

References