Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 349799..351147 Replicon chromosome
Accession NZ_LR134168
Organism Haemophilus influenzae strain NCTC11394

Toxin (Protein)


Gene name HipT Uniprot ID A0A2X4XRN4
Locus tag ELZ62_RS01770 Protein ID WP_005690165.1
Coordinates 350116..351147 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F9GV76
Locus tag ELZ62_RS01765 Protein ID WP_005635266.1
Coordinates 349799..350119 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ62_RS01725 345220..345498 + 279 WP_005661211.1 cell division protein FtsB -
ELZ62_RS01730 345498..346175 + 678 WP_005690174.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
ELZ62_RS01735 346172..346648 + 477 WP_005661209.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
ELZ62_RS01740 346953..347387 - 435 WP_005690172.1 D-tyrosyl-tRNA(Tyr) deacylase -
ELZ62_RS01745 347384..347824 - 441 WP_005667635.1 FMN-binding protein MioC -
ELZ62_RS01750 347922..348140 - 219 WP_005650820.1 cell division protein ZapB -
ELZ62_RS01755 348302..349303 + 1002 WP_005690169.1 class II fructose-bisphosphatase -
ELZ62_RS01760 349503..349811 + 309 WP_005690167.1 helix-turn-helix domain-containing protein -
ELZ62_RS01765 349799..350119 + 321 WP_005635266.1 type II toxin-antitoxin system HipA family toxin Antitoxin
ELZ62_RS01770 350116..351147 + 1032 WP_005690165.1 type II toxin-antitoxin system HipA family toxin Toxin
ELZ62_RS01775 351231..352889 - 1659 WP_015701796.1 thiol reductant ABC exporter subunit CydC -
ELZ62_RS01780 352882..354627 - 1746 WP_126507558.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39855.45 Da        Isoelectric Point: 6.5777

>T286946 WP_005690165.1 NZ_LR134168:350116-351147 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKTMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLAFLNLLNEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12441.11 Da        Isoelectric Point: 5.9670

>AT286946 WP_005635266.1 NZ_LR134168:349799-350119 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4XRN4

Antitoxin

Source ID Structure
AlphaFold DB F9GV76

References