Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2040168..2040803 Replicon chromosome
Accession NZ_LR134167
Organism Avibacterium volantium strain NCTC3438

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ELZ61_RS09680 Protein ID WP_126373258.1
Coordinates 2040498..2040803 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ELZ61_RS09675 Protein ID WP_126373681.1
Coordinates 2040168..2040488 (-) Length 107 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ61_RS09645 2035601..2036239 - 639 WP_126373250.1 phosphoribosylglycinamide formyltransferase -
ELZ61_RS09650 2036239..2037276 - 1038 WP_126373252.1 phosphoribosylformylglycinamidine cyclo-ligase -
ELZ61_RS09655 2037509..2037977 + 469 Protein_1863 hypothetical protein -
ELZ61_RS09660 2038087..2038812 - 726 WP_115249505.1 TerC family protein -
ELZ61_RS09665 2038883..2039551 - 669 WP_126373254.1 DNA mismatch repair endonuclease MutH -
ELZ61_RS09670 2039582..2040121 - 540 WP_126373256.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
ELZ61_RS09675 2040168..2040488 - 321 WP_126373681.1 HigA family addiction module antidote protein Antitoxin
ELZ61_RS09680 2040498..2040803 - 306 WP_126373258.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELZ61_RS09685 2040945..2042324 - 1380 WP_126373260.1 OmpP1/FadL family transporter -
ELZ61_RS09690 2042575..2044233 - 1659 WP_126373262.1 putative transporter -
ELZ61_RS09695 2044444..2044953 + 510 WP_126373264.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-97)

Antitoxin

(18-69)


Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 12151.93 Da        Isoelectric Point: 9.2219

>T286942 WP_126373258.1 NZ_LR134167:c2040803-2040498 [Avibacterium volantium]
MFNLTAKHFKDDYLYRFFQYGELHSKIPANLTKVLARKLDMINAAENLNDLRVPPANHLELLEPKENKRYSIRVNKQYRL
IFHFDNGELSQLYLDPHRYDL

Download         Length: 306 bp


Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12059.74 Da        Isoelectric Point: 7.3188

>AT286942 WP_126373681.1 NZ_LR134167:c2040488-2040168 [Avibacterium volantium]
MFSTQRKPTSVGEILQEEFLQPLNLKVSDLAEILDVHRNTASSLVNSHSKVTLEMAVKLAKAFGTSPEFWINLQNNLDLW
ELNHNARFQQSLDKVKIANYRASFSV

Download         Length: 321 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References