Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1425935..1426527 Replicon chromosome
Accession NZ_LR134167
Organism Avibacterium volantium strain NCTC3438

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ELZ61_RS06925 Protein ID WP_126372430.1
Coordinates 1426249..1426527 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ELZ61_RS06920 Protein ID WP_197717477.1
Coordinates 1425935..1426234 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ61_RS06890 1421015..1422139 + 1125 WP_126372422.1 bifunctional chorismate mutase/prephenate dehydrogenase -
ELZ61_RS06895 1422317..1423228 + 912 WP_126372424.1 cytidine deaminase -
ELZ61_RS06900 1423266..1423814 - 549 WP_115249597.1 HAD family hydrolase -
ELZ61_RS06905 1423819..1424754 - 936 WP_126372426.1 KpsF/GutQ family sugar isomerase -
ELZ61_RS06915 1425329..1425778 - 450 WP_126372428.1 macrodomain Ter protein MatP -
ELZ61_RS06920 1425935..1426234 - 300 WP_197717477.1 HigA family addiction module antidote protein Antitoxin
ELZ61_RS06925 1426249..1426527 - 279 WP_126372430.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELZ61_RS06930 1426663..1428435 + 1773 WP_126372433.1 Lon protease family protein -
ELZ61_RS06935 1428565..1429218 - 654 WP_021724593.1 IS1595 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1428565..1429218 653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10864.49 Da        Isoelectric Point: 9.1907

>T286938 WP_126372430.1 NZ_LR134167:c1426527-1426249 [Avibacterium volantium]
MITHFSCKETQAFFEGKRIRRFIPFEKVAMRKLQQLNAATELNFLKIPPGNHLEQLSGDRKGQYSIRINDQWRICFTWLN
GHAADVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11287.99 Da        Isoelectric Point: 6.7234

>AT286938 WP_197717477.1 NZ_LR134167:c1426234-1425935 [Avibacterium volantium]
IMIREIPLSHPGEILLEDWLKPLGISQYALAKAISVPPRRINEIVKGKRSITPDTALRLATFFGTDAQSWLNMQSHYDTE
QTRSIINEDLSHIIPYQFA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References