286934

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4469347..4469949 Replicon chromosome
Accession NZ_LR134164
Organism Enterobacter hormaechei strain NCTC11571

Toxin (Protein)


Gene name higB Uniprot ID A0A155DUZ6
Locus tag EL051_RS21400 Protein ID WP_022649837.1
Coordinates 4469638..4469949 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL051_RS21395 Protein ID WP_032626927.1
Coordinates 4469347..4469637 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL051_RS21380 4466845..4467747 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
EL051_RS21385 4467744..4468379 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
EL051_RS21390 4468376..4469305 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
EL051_RS21395 4469347..4469637 - 291 WP_032626927.1 helix-turn-helix domain-containing protein Antitoxin
EL051_RS21400 4469638..4469949 - 312 WP_022649837.1 hypothetical protein Toxin
EL051_RS21405 4470098..4471039 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
EL051_RS21410 4471084..4471521 - 438 WP_063150747.1 D-tyrosyl-tRNA(Tyr) deacylase -
EL051_RS21415 4471518..4472400 - 883 Protein_4115 virulence factor BrkB family protein -
EL051_RS21420 4472394..4472993 - 600 WP_003861947.1 glucose-1-phosphatase -
EL051_RS21425 4473112..4473912 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -
EL051_RS21430 4473947..4474843 - 897 WP_038416951.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12148.13 Da        Isoelectric Point: 9.4455

>T286934 WP_022649837.1 NZ_LR134164:c4469949-4469638 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNTGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10685.18 Da        Isoelectric Point: 10.5888

>AT286934 WP_032626927.1 NZ_LR134164:c4469637-4469347 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155DUZ6

Antitoxin

Source ID Structure

References