Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 95828..96474 Replicon chromosome
Accession NZ_LR134164
Organism Enterobacter hormaechei strain NCTC11571

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL051_RS00480 Protein ID WP_047050720.1
Coordinates 96124..96474 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E7BLR3
Locus tag EL051_RS00475 Protein ID WP_023299004.1
Coordinates 95828..96127 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL051_RS00450 91296..91880 - 585 WP_023299002.1 type 1 fimbrial protein -
EL051_RS00455 91933..92535 - 603 WP_045308231.1 LuxR C-terminal-related transcriptional regulator -
EL051_RS00460 93370..94158 + 789 WP_126291583.1 winged helix-turn-helix domain-containing protein -
EL051_RS00465 94160..94639 + 480 WP_126314416.1 hypothetical protein -
EL051_RS00470 94882..95763 + 882 WP_032622044.1 helix-turn-helix domain-containing protein -
EL051_RS00475 95828..96127 - 300 WP_023299004.1 XRE family transcriptional regulator Antitoxin
EL051_RS00480 96124..96474 - 351 WP_047050720.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL051_RS00485 96629..97044 - 416 Protein_95 hydroxyacid dehydrogenase -
EL051_RS00490 97095..97436 - 342 WP_063163341.1 SymE family type I addiction module toxin -
EL051_RS00495 97573..97749 + 177 WP_126314418.1 toxin-antitoxin system HicB family antitoxin -
EL051_RS00500 98031..99998 - 1968 WP_045897277.1 RNA-directed DNA polymerase -
EL051_RS00505 99999..101252 - 1254 WP_126314420.1 RNA-directed DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 81346..101252 19906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13497.59 Da        Isoelectric Point: 8.8416

>T286925 WP_047050720.1 NZ_LR134164:c96474-96124 [Enterobacter hormaechei]
MWTVLFSKVFEQWLLEQEDGLQEKVLADLLNLQNYGPRLPRPYADTVKGSQYKNMKELRIQYAGRPVRAFFAFDPVRQAI
VLCAGDKRNDKTFYEKLIRIADAEFTLHLTSLEAAK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11101.81 Da        Isoelectric Point: 5.7151

>AT286925 WP_023299004.1 NZ_LR134164:c96127-95828 [Enterobacter hormaechei]
VKTLNEVIASRSPESQQRIQEMAEEMFLETGLQLLREELQLSQKHVADLMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKQVAFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References