Detailed information of TA system TA286925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 95828..96474
• Replicon: chromosome
• Accession: NZ_LR134164
• Organism: Enterobacter hormaechei strain NCTC11571

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EL051_RS00480
• Protein ID: WP_047050720.1
• Coordinates: 96124..96474 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A9E7BLR3
• Locus tag: EL051_RS00475
• Protein ID: WP_023299004.1
• Coordinates: 95828..96127 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL051_RS00450	91296..91880	-	585	WP_023299002.1	type 1 fimbrial protein	-
EL051_RS00455	91933..92535	-	603	WP_045308231.1	LuxR C-terminal-related transcriptional regulator	-
EL051_RS00460	93370..94158	+	789	WP_126291583.1	winged helix-turn-helix domain-containing protein	-
EL051_RS00465	94160..94639	+	480	WP_126314416.1	hypothetical protein	-
EL051_RS00470	94882..95763	+	882	WP_032622044.1	helix-turn-helix domain-containing protein	-
EL051_RS00475	95828..96127	-	300	WP_023299004.1	XRE family transcriptional regulator	Antitoxin
EL051_RS00480	96124..96474	-	351	WP_047050720.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EL051_RS00485	96629..97044	-	416	Protein_95	hydroxyacid dehydrogenase	-
EL051_RS00490	97095..97436	-	342	WP_063163341.1	SymE family type I addiction module toxin	-
EL051_RS00495	97573..97749	+	177	WP_126314418.1	toxin-antitoxin system HicB family antitoxin	-
EL051_RS00500	98031..99998	-	1968	WP_045897277.1	RNA-directed DNA polymerase	-
EL051_RS00505	99999..101252	-	1254	WP_126314420.1	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	81346..101252	19906

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13497.59 Da
• Isoelectric Point: 8.8416

>T286925 WP_047050720.1 NZ_LR134164:c96474-96124 [Enterobacter hormaechei]
MWTVLFSKVFEQWLLEQEDGLQEKVLADLLNLQNYGPRLPRPYADTVKGSQYKNMKELRIQYAGRPVRAFFAFDPVRQAI
VLCAGDKRNDKTFYEKLIRIADAEFTLHLTSLEAAK

Nucleotide

• Length: 351 bp

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11101.81 Da
• Isoelectric Point: 5.7151

>AT286925 WP_023299004.1 NZ_LR134164:c96127-95828 [Enterobacter hormaechei]
VKTLNEVIASRSPESQQRIQEMAEEMFLETGLQLLREELQLSQKHVADLMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKQVAFHL

Nucleotide

• Length: 300 bp