Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4250077..4250660 Replicon chromosome
Accession NZ_LR134161
Organism Yersinia enterocolitica subsp. enterocolitica strain NCTC13629

Toxin (Protein)


Gene name higB Uniprot ID A0A7U7FJS5
Locus tag EL026_RS20035 Protein ID WP_005162526.1
Coordinates 4250077..4250355 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL026_RS20040 Protein ID WP_005162529.1
Coordinates 4250355..4250660 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL026_RS20015 4245558..4246505 - 948 WP_005162520.1 trehalose operon repressor TreR -
EL026_RS20030 4247277..4249997 + 2721 WP_005162523.1 magnesium-translocating P-type ATPase -
EL026_RS20035 4250077..4250355 + 279 WP_005162526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL026_RS20040 4250355..4250660 + 306 WP_005162529.1 HigA family addiction module antidote protein Antitoxin
EL026_RS20045 4250732..4252660 - 1929 WP_005162532.1 BglG family transcription antiterminator -
EL026_RS20050 4252733..4253974 - 1242 WP_005162536.1 lactonase family protein -
EL026_RS20055 4254104..4254844 - 741 Protein_3760 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10694.10 Da        Isoelectric Point: 7.4011

>T286915 WP_005162526.1 NZ_LR134161:4250077-4250355 [Yersinia enterocolitica subsp. enterocolitica]
MIKSWKHKGLQRFFETGSAAGINPQHVKRIRDRLRFIDLAETIEDVNVAGYKLHPLQGEREGIWSVTVSGNWRITFEFTA
GDAFILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10934.77 Da        Isoelectric Point: 6.7158

>AT286915 WP_005162529.1 NZ_LR134161:4250355-4250660 [Yersinia enterocolitica subsp. enterocolitica]
MKMHNPPHPGEMIEGILEDLGLGIREFARALNVSPSTVQRLVACKAAISPEMAVKLAAVLGSTPAMWLRLQAAYDLGKAE
ENVDVSNLTKLYKPDPISLHS

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FJS5

Antitoxin

Source ID Structure

References