286892

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3679829..3680370 Replicon chromosome
Accession NZ_LR134152
Organism Escherichia coli strain NCTC9104

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag EL040_RS18000 Protein ID WP_000615983.1
Coordinates 3680092..3680370 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag EL040_RS17995 Protein ID WP_000729703.1
Coordinates 3679829..3680089 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL040_RS17975 3675503..3676289 - 787 Protein_3499 putative lateral flagellar export/assembly protein LafU -
EL040_RS17980 3676261..3677973 + 1713 Protein_3500 flagellar biosynthesis protein FlhA -
EL040_RS17985 3678197..3678694 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
EL040_RS17990 3678870..3679619 - 750 WP_000056849.1 C40 family peptidase -
EL040_RS17995 3679829..3680089 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL040_RS18000 3680092..3680370 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL040_RS18005 3680526..3681266 + 741 WP_001225679.1 murein L,D-transpeptidase -
EL040_RS18010 3681237..3682004 - 768 WP_000333380.1 class II glutamine amidotransferase -
EL040_RS18015 3682210..3682788 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T286892 WP_000615983.1 NZ_LR134152:3680092-3680370 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT286892 WP_000729703.1 NZ_LR134152:3679829-3680089 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References