Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3673679..3674325 Replicon chromosome
Accession NZ_LR134152
Organism Escherichia coli strain NCTC9104

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag EL040_RS17960 Protein ID WP_126350685.1
Coordinates 3673679..3674029 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag EL040_RS17965 Protein ID WP_000554758.1
Coordinates 3674032..3674325 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- 3669221..3669301 - 81 NuclAT_11 - -
- 3669221..3669301 - 81 NuclAT_11 - -
- 3669221..3669301 - 81 NuclAT_11 - -
- 3669221..3669301 - 81 NuclAT_11 - -
EL040_RS17935 3669897..3670355 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
EL040_RS17940 3670616..3672073 + 1458 WP_001292994.1 cytosol nonspecific dipeptidase -
EL040_RS17945 3672130..3672651 - 522 Protein_3493 peptide chain release factor H -
EL040_RS17950 3672647..3672853 - 207 Protein_3494 RtcB family protein -
EL040_RS17955 3673170..3673621 - 452 Protein_3495 GNAT family N-acetyltransferase -
EL040_RS17960 3673679..3674029 - 351 WP_126350685.1 type II toxin-antitoxin system YafO family toxin Toxin
EL040_RS17965 3674032..3674325 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
EL040_RS17970 3674377..3675432 - 1056 WP_001226164.1 DNA polymerase IV -
EL040_RS17975 3675503..3676289 - 787 Protein_3499 putative lateral flagellar export/assembly protein LafU -
EL040_RS17980 3676261..3677973 + 1713 Protein_3500 flagellar biosynthesis protein FlhA -
EL040_RS17985 3678197..3678694 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13524.43 Da        Isoelectric Point: 6.0794

>T286891 WP_126350685.1 NZ_LR134152:c3674029-3673679 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNN

Download         Length: 351 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT286891 WP_000554758.1 NZ_LR134152:c3674325-3674032 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References