Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 711885..712578 Replicon chromosome
Accession NZ_LR134152
Organism Escherichia coli strain NCTC9104

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EL040_RS03445 Protein ID WP_000415584.1
Coordinates 711885..712181 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EL040_RS03450 Protein ID WP_000650107.1
Coordinates 712183..712578 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL040_RS03410 706973..707287 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
EL040_RS03415 707318..707899 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EL040_RS03420 708218..708550 + 333 WP_000917684.1 DUF2645 family protein -
EL040_RS03425 708596..709945 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
EL040_RS03430 709942..710601 - 660 WP_001221493.1 two-component system response regulator QseB -
EL040_RS03435 710753..711145 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EL040_RS03440 711198..711680 + 483 WP_000183505.1 transcriptional regulator -
EL040_RS03445 711885..712181 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EL040_RS03450 712183..712578 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EL040_RS03455 712711..714318 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
EL040_RS03460 714456..716714 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T286879 WP_000415584.1 NZ_LR134152:711885-712181 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT286879 WP_000650107.1 NZ_LR134152:712183-712578 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References