Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3939041..3940380 Replicon chromosome
Accession NZ_LR134151
Organism Serratia plymuthica strain NCTC8900

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag EL066_RS18840 Protein ID WP_126484555.1
Coordinates 3939349..3940380 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A1B1KUV7
Locus tag EL066_RS18835 Protein ID WP_006318221.1
Coordinates 3939041..3939352 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL066_RS18805 3934294..3935094 - 801 WP_126484543.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
EL066_RS18810 3935091..3935885 - 795 WP_126484545.1 hydroxyethylthiazole kinase -
EL066_RS18815 3936082..3936507 + 426 WP_126484547.1 GNAT family N-acetyltransferase -
EL066_RS18820 3936670..3937910 - 1241 Protein_3639 MFS transporter -
EL066_RS18825 3938005..3938448 + 444 WP_126484551.1 helix-turn-helix transcriptional regulator -
EL066_RS18830 3938709..3939056 + 348 WP_126484553.1 XRE family transcriptional regulator -
EL066_RS18835 3939041..3939352 + 312 WP_006318221.1 HipA N-terminal domain-containing protein Antitoxin
EL066_RS18840 3939349..3940380 + 1032 WP_126484555.1 HipA domain-containing protein Toxin
EL066_RS18845 3940442..3941191 + 750 WP_126484557.1 23S rRNA pseudouridine(2604) synthase RluF -
EL066_RS18850 3941273..3944326 - 3054 WP_126484559.1 autotransporter outer membrane beta-barrel domain-containing protein -
EL066_RS18855 3944557..3944871 - 315 WP_006318086.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3939041..3956031 16990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 38588.22 Da        Isoelectric Point: 6.0557

>T286873 WP_126484555.1 NZ_LR134151:3939349-3940380 [Serratia plymuthica]
MNPDRCLINLTPLKAPEQITGYSKQGIKQLFGSAKIALTLPFTRREFIQELPERQKGMSISGYQPKLSLSLEEGELHVVN
NDGTYILKPSPEEYPHQAENEHATMTVMARLKFVVPPFGLMRFKADEDRPDELAFVIKRYDRIGPDRVRLHQEQLDGAMG
INDKYGYVDGKKDISYEKAAKFLNHTVSNGLSSKRDVFLRILYAYVLGNNDFHLRNLGIIHPENASPYVAPVYDFISVAP
YPAAFGEYLALPLLECEENDAGIAPGINSPYGEYIGVDFILLAEGMDVNPKLAKKWLAEVVKSHQLIIDTYTESHMPAEQ
REAVLSYVARRITLLGVTELKTA

Download         Length: 1032 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11775.50 Da        Isoelectric Point: 5.8715

>AT286873 WP_006318221.1 NZ_LR134151:3939041-3939352 [Serratia plymuthica]
MARKIEVWLYGKAVGSLTEEKEGYTFGYYSGYSGPAVSLSMRVRPEPYFSEELHPFFKGLAPEGWLRKRYAEIQKIDDRD
LFGLLMQNGNDLLGAVVFKEMSP

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KUV7

References