286855

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2478269..2478768 Replicon chromosome
Accession NZ_LR134139
Organism Staphylococcus aureus strain NCTC4163

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ELZ55_RS12980 Protein ID WP_000074044.1
Coordinates 2478269..2478511 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag ELZ55_RS12985 Protein ID WP_000587618.1
Coordinates 2478511..2478768 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ55_RS12960 2473574..2474761 - 1188 WP_000026189.1 MFS transporter -
ELZ55_RS12965 2475157..2475933 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
ELZ55_RS12970 2475926..2476588 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
ELZ55_RS12975 2476836..2477912 - 1077 WP_042727737.1 M42 family metallopeptidase -
ELZ55_RS12980 2478269..2478511 - 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
ELZ55_RS12985 2478511..2478768 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ55_RS12995 2479127..2479582 + 456 WP_000732082.1 DUF1307 domain-containing protein -
ELZ55_RS13000 2479750..2481327 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
ELZ55_RS13005 2481522..2482271 + 750 WP_000072459.1 hypothetical protein -
ELZ55_RS13010 2482502..2483695 - 1194 WP_000675411.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T286855 WP_000074044.1 NZ_LR134139:c2478511-2478269 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT286855 WP_000587618.1 NZ_LR134139:c2478768-2478511 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References