Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2419828..2420345 Replicon chromosome
Accession NZ_LR134139
Organism Staphylococcus aureus strain NCTC4163

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ELZ55_RS12660 Protein ID WP_000113262.1
Coordinates 2419828..2420094 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ELZ55_RS12665 Protein ID WP_000584499.1
Coordinates 2420094..2420345 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ55_RS12630 2415247..2415783 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
ELZ55_RS12635 2416017..2416841 - 825 WP_000572040.1 formate/nitrite transporter family protein -
ELZ55_RS12640 2417058..2417240 - 183 WP_000079142.1 hypothetical protein -
ELZ55_RS12645 2417327..2417794 - 468 WP_000153344.1 SRPBCC domain-containing protein -
ELZ55_RS12650 2417980..2419533 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ELZ55_RS12655 2419722..2419793 - 72 Protein_2329 hypothetical protein -
ELZ55_RS12660 2419828..2420094 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ELZ55_RS12665 2420094..2420345 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ55_RS12670 2420510..2420611 - 102 WP_031774922.1 hypothetical protein -
ELZ55_RS12675 2420618..2421217 - 600 WP_000162813.1 DsbA family protein -
ELZ55_RS12680 2421236..2421598 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ELZ55_RS12685 2421853..2423103 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
ELZ55_RS12690 2423182..2424501 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2423182..2424501 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286853 WP_000113262.1 NZ_LR134139:c2420094-2419828 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286853 WP_000584499.1 NZ_LR134139:c2420345-2420094 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References