Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2278859..2279568 Replicon chromosome
Accession NZ_LR134136
Organism Atlantibacter hermannii strain NCTC12129

Toxin (Protein)


Gene name mqsR Uniprot ID H5V274
Locus tag EL032_RS10860 Protein ID WP_002435659.1
Coordinates 2279263..2279568 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID H5V273
Locus tag EL032_RS10855 Protein ID WP_002435658.1
Coordinates 2278859..2279263 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL032_RS10835 (NCTC12129_02481) 2274691..2276244 + 1554 WP_170170514.1 urea ABC transporter permease subunit UrtB -
EL032_RS10840 (NCTC12129_02482) 2276244..2277318 + 1075 Protein_2145 urea ABC transporter permease subunit UrtC -
EL032_RS10845 2277318..2278117 + 800 Protein_2146 urea ABC transporter ATP-binding protein UrtD -
EL032_RS10850 (NCTC12129_02484) 2278127..2278825 + 699 WP_002435657.1 urea ABC transporter ATP-binding subunit UrtE -
EL032_RS10855 (NCTC12129_02485) 2278859..2279263 - 405 WP_002435658.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EL032_RS10860 (NCTC12129_02486) 2279263..2279568 - 306 WP_002435659.1 type II toxin-antitoxin system MqsR family toxin Toxin
EL032_RS10865 (NCTC12129_02487) 2279648..2280842 - 1195 Protein_2150 efflux MFS transporter YdeE -
EL032_RS10870 (NCTC12129_02488) 2281041..2281936 + 896 Protein_2151 O-acetylserine/cysteine exporter -
EL032_RS10880 (NCTC12129_02490) 2282660..2282869 - 210 WP_040459853.1 multiple antibiotic resistance regulatory protein MarB -
EL032_RS10885 (NCTC12129_02491) 2282902..2283276 - 375 WP_002435664.1 MDR efflux pump AcrAB transcriptional activator MarA -
EL032_RS10890 (NCTC12129_02492) 2283294..2283728 - 435 WP_040459814.1 multiple antibiotic resistance transcriptional regulator MarR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-100)

Antitoxin

Antitoxin MqsA

(4-131)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11652.75 Da        Isoelectric Point: 9.4481

>T286837 WP_002435659.1 NZ_LR134136:c2279568-2279263 [Atlantibacter hermannii]
MRKGTPNVPLSVVKEMVRSGKVKTTFTATQGALELGFPAPVLPLMCKVVLLLDQSHFYKSMTAYHDETIWHDVYRTRFDE
RHIYLKLIVKDDVLIVSFKEL

Download         Length: 306 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14921.97 Da        Isoelectric Point: 7.6663

>AT286837 WP_002435658.1 NZ_LR134136:c2279263-2278859 [Atlantibacter hermannii]
MKTCPVCGGGHLTHESRDLPYEYKGSKTTLRGIVGEYCNSCGEIIFTPEESNAFSAQASAFRTAVNAESFDPTLFTRVRK
NLRIDQQQAGMLFGGGVNAFSRYETGKTTPPIAVVKLFKMFDKFPELFEEYKSL

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H5V274

Antitoxin

Source ID Structure
AlphaFold DB H5V273

References