Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1626105..1626751 Replicon chromosome
Accession NZ_LR134136
Organism Atlantibacter hermannii strain NCTC12129

Toxin (Protein)


Gene name higB Uniprot ID H5UXB4
Locus tag EL032_RS07560 Protein ID WP_002463190.1
Coordinates 1626105..1626458 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID H5UXB3
Locus tag EL032_RS07565 Protein ID WP_002463188.1
Coordinates 1626455..1626751 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL032_RS07550 1621501..1624624 - 3124 Protein_1481 MdtB/MuxB family multidrug efflux RND transporter permease subunit -
EL032_RS07555 (NCTC12129_01741) 1624624..1625877 - 1254 WP_002463191.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
EL032_RS07560 (NCTC12129_01743) 1626105..1626458 + 354 WP_002463190.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL032_RS07565 (NCTC12129_01744) 1626455..1626751 + 297 WP_002463188.1 XRE family transcriptional regulator Antitoxin
EL032_RS07570 (NCTC12129_01745) 1626774..1628127 - 1354 Protein_1485 molecular chaperone -
EL032_RS07575 (NCTC12129_01747) 1628260..1629114 + 855 WP_002463186.1 DNA-3-methyladenine glycosylase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-99)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-88)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13569.72 Da        Isoelectric Point: 10.0566

>T286832 WP_002463190.1 NZ_LR134136:1626105-1626458 [Atlantibacter hermannii]
MTWTVVLTPEFEQWFDKQEAGLQDRINMMITLLEISGPNLGRPHVDTLVGSRYPNMKELRIQYAGEPWRVGFAFNHRQQA
VLLYGGQKTGKKRFYTLLIAQVDAIFARDLARKKETL

Download         Length: 354 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11034.79 Da        Isoelectric Point: 8.5172

>AT286832 WP_002463188.1 NZ_LR134136:1626455-1626751 [Atlantibacter hermannii]
MKTFQEKLAEYSPERRAKIERMAEAFAAENGLPTLREMRAMSQQELAERLGVTQPAVAAMERRGEDIKVSTLKRYAEALG
GELKITIELPEGRKVISL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H5UXB4

Antitoxin

Source ID Structure
AlphaFold DB H5UXB3

References