Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1717072..1717721 Replicon chromosome
Accession NZ_LR134117
Organism Serratia odorifera strain NCTC11214

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL065_RS08440 Protein ID WP_128135925.1
Coordinates 1717371..1717721 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID D4DZY8
Locus tag EL065_RS08435 Protein ID WP_004957249.1
Coordinates 1717072..1717371 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL065_RS08415 1712977..1713996 + 1020 WP_004957238.1 dipeptide ABC transporter permease DppB -
EL065_RS08420 1714008..1714910 + 903 WP_004957240.1 dipeptide ABC transporter permease DppC -
EL065_RS08425 1714925..1715890 + 966 Protein_1628 dipeptide ABC transporter ATP-binding protein -
EL065_RS08430 1715903..1716898 + 996 WP_004957246.1 ABC transporter ATP-binding protein -
EL065_RS08435 1717072..1717371 - 300 WP_004957249.1 helix-turn-helix domain-containing protein Antitoxin
EL065_RS08440 1717371..1717721 - 351 WP_128135925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL065_RS08445 1718023..1719679 - 1657 Protein_1632 cellulose biosynthesis protein BcsG -
EL065_RS08450 1719676..1719879 - 204 WP_004957257.1 cellulose biosynthesis protein BcsF -
EL065_RS08455 1719873..1721435 - 1563 WP_004957260.1 cellulose biosynthesis protein BcsE -
EL065_RS08460 1721639..1721830 + 192 WP_004957267.1 hypothetical protein -
EL065_RS08465 1721834..1722562 + 729 WP_004957269.1 cellulose synthase operon protein YhjQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13368.54 Da        Isoelectric Point: 9.6538

>T286823 WP_128135925.1 NZ_LR134117:c1717721-1717371 [Serratia odorifera]
MWTIVTRPRFDQWFYRQTDRVQEEMLAVLTLLQQDGPNLGRPQVDTLKGSAYGNMKELRVQTAGHPIRACFAFDPHRQAI
VLCAADKKGMGRRFYQQLIKTAMPSMPPICKTLENE

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10999.80 Da        Isoelectric Point: 9.7243

>AT286823 WP_004957249.1 NZ_LR134117:c1717371-1717072 [Serratia odorifera]
MATLEHLLAQRSAESRERIAARADEIRQEIALAKIREELNISQKQLADAMGIKQPAVAKMEKVDNDPKLSTLKRYVKALG
GELSLDVTLPDGKRIALHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4FLQ4

References