Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 479396..479979 Replicon chromosome
Accession NZ_LR134116
Organism Yersinia intermedia strain NCTC11469

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL015_RS02185 Protein ID WP_005188495.1
Coordinates 479701..479979 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL015_RS02180 Protein ID WP_032906974.1
Coordinates 479396..479701 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL015_RS02165 475397..476509 + 1113 WP_032906975.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
EL015_RS02170 476513..477253 + 741 WP_005188504.1 KDGP aldolase family protein -
EL015_RS02175 477378..479306 + 1929 WP_072103864.1 BglG family transcription antiterminator -
EL015_RS02180 479396..479701 - 306 WP_032906974.1 HigA family addiction module antidote protein Antitoxin
EL015_RS02185 479701..479979 - 279 WP_005188495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL015_RS02190 480060..482792 - 2733 WP_005188491.1 magnesium-translocating P-type ATPase -
EL015_RS02195 483317..484264 + 948 WP_005188487.1 trehalose operon repressor TreR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10623.04 Da        Isoelectric Point: 8.0850

>T286805 WP_005188495.1 NZ_LR134116:c479979-479701 [Yersinia intermedia]
MIKSWKHKGLQRFFETGSAAGINPQHVKRLRGRLRFIDLAETIEDVNVAGCKLHSLQGDREGLWSVTVSGNWRITFEFKD
GDAFILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11010.78 Da        Isoelectric Point: 6.0643

>AT286805 WP_032906974.1 NZ_LR134116:c479701-479396 [Yersinia intermedia]
MKMHNPPHPGEMIEGILEDLDLGIRELARALNVAPSTVQRLVSCHSAVSPEMAVKLAAVLGSTPAMWLRLQAAYDLGKAE
ENIDISNLTKLYKPDPVSLHN

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References