Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 150707..151242 Replicon plasmid 2
Accession NZ_LR134106
Organism Enterococcus faecium isolate E6043

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag ELZ65_RS14690 Protein ID WP_002314366.1
Coordinates 150707..150979 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag ELZ65_RS14695 Protein ID WP_002297422.1
Coordinates 150979..151242 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ65_RS14655 146263..146906 + 644 Protein_153 transposase -
ELZ65_RS14660 146982..147662 + 681 WP_002331383.1 IS6-like element IS1216 family transposase -
ELZ65_RS14665 147717..148073 - 357 Protein_155 hypothetical protein -
ELZ65_RS14670 148333..148881 - 549 WP_002292681.1 hypothetical protein -
ELZ65_RS14675 148882..149739 - 858 WP_002292680.1 AAA family ATPase -
ELZ65_RS14680 150025..150311 - 287 Protein_158 type II toxin-antitoxin system RelE/ParE family toxin -
ELZ65_RS14685 150301..150630 - 330 WP_002292678.1 AbrB family transcriptional regulator -
ELZ65_RS14690 150707..150979 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
ELZ65_RS14695 150979..151242 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ65_RS14700 151476..152384 + 909 Protein_162 IS982 family transposase -
ELZ65_RS14705 152387..153562 - 1176 WP_002336205.1 MFS transporter -
ELZ65_RS14710 153565..155814 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') / aph(2'')-Ia - 1..164095 164095
- inside IScluster/Tn - - 138172..161843 23671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T286801 WP_002314366.1 NZ_LR134106:c150979-150707 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT286801 WP_002297422.1 NZ_LR134106:c151242-150979 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References