Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2506490..2507007 Replicon chromosome
Accession NZ_LR134093
Organism Staphylococcus aureus strain NCTC11965

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag ELZ56_RS12905 Protein ID WP_000251928.1
Coordinates 2506490..2506756 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag ELZ56_RS12910 Protein ID WP_000584497.1
Coordinates 2506756..2507007 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ56_RS12880 2501698..2502234 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
ELZ56_RS12885 2502702..2503526 - 825 WP_000594640.1 formate/nitrite transporter family protein -
ELZ56_RS12890 2503729..2503911 - 183 WP_000079140.1 hypothetical protein -
ELZ56_RS12895 2503997..2504464 - 468 WP_000153340.1 SRPBCC domain-containing protein -
ELZ56_RS12900 2504650..2506197 - 1548 WP_126523608.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ELZ56_RS12905 2506490..2506756 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
ELZ56_RS12910 2506756..2507007 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ56_RS12915 2507171..2507271 - 101 Protein_2396 hypothetical protein -
ELZ56_RS12920 2507278..2507877 - 600 WP_000162804.1 DsbA family protein -
ELZ56_RS12925 2507896..2508258 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ELZ56_RS12930 2508513..2509763 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
ELZ56_RS12935 2509860..2510591 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
ELZ56_RS12940 2510588..2511307 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T286793 WP_000251928.1 NZ_LR134093:c2506756-2506490 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT286793 WP_000584497.1 NZ_LR134093:c2507007-2506756 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References