Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2047191..2047490 Replicon chromosome
Accession NZ_LR134093
Organism Staphylococcus aureus strain NCTC11965

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag ELZ56_RS10335 Protein ID WP_011447039.1
Coordinates 2047314..2047490 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2047191..2047246 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ56_RS10290 2042521..2042781 + 261 WP_001791826.1 hypothetical protein -
ELZ56_RS10295 2042834..2043184 - 351 WP_000702263.1 complement inhibitor SCIN-A -
ELZ56_RS10300 2043870..2044319 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
ELZ56_RS10305 2044414..2044749 - 336 Protein_1909 SH3 domain-containing protein -
ELZ56_RS10315 2045399..2045890 - 492 WP_000919350.1 staphylokinase -
ELZ56_RS10320 2046081..2046836 - 756 WP_000861038.1 CHAP domain-containing protein -
ELZ56_RS10325 2046848..2047102 - 255 WP_000611512.1 phage holin -
ELZ56_RS10330 2047154..2047261 + 108 WP_001791821.1 hypothetical protein -
- 2047183..2047322 + 140 NuclAT_0 - -
- 2047183..2047322 + 140 NuclAT_0 - -
- 2047183..2047322 + 140 NuclAT_0 - -
- 2047183..2047322 + 140 NuclAT_0 - -
- 2047191..2047246 + 56 - - Antitoxin
ELZ56_RS10335 2047314..2047490 - 177 WP_011447039.1 putative holin-like toxin Toxin
ELZ56_RS10340 2047599..2048372 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
ELZ56_RS10350 2048793..2049167 - 375 Protein_1916 hypothetical protein -
ELZ56_RS10355 2049223..2049510 - 288 WP_001040259.1 hypothetical protein -
ELZ56_RS10360 2049557..2049709 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL / hld 2037060..2120318 83258


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T286786 WP_011447039.1 NZ_LR134093:c2047490-2047314 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT286786 NZ_LR134093:2047191-2047246 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References