Detailed information of TA system TA286785

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2047183..2047490
• Replicon: chromosome
• Accession: NZ_LR134093
• Organism: Staphylococcus aureus strain NCTC11965

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ELZ56_RS10335
• Protein ID: WP_011447039.1
• Coordinates: 2047314..2047490 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2047183..2047322 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELZ56_RS10290	2042521..2042781	+	261	WP_001791826.1	hypothetical protein	-
ELZ56_RS10295	2042834..2043184	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
ELZ56_RS10300	2043870..2044319	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
ELZ56_RS10305	2044414..2044749	-	336	Protein_1909	SH3 domain-containing protein	-
ELZ56_RS10315	2045399..2045890	-	492	WP_000919350.1	staphylokinase	-
ELZ56_RS10320	2046081..2046836	-	756	WP_000861038.1	CHAP domain-containing protein	-
ELZ56_RS10325	2046848..2047102	-	255	WP_000611512.1	phage holin	-
ELZ56_RS10330	2047154..2047261	+	108	WP_001791821.1	hypothetical protein	-
-	2047183..2047322	+	140	NuclAT_0	-	Antitoxin
-	2047183..2047322	+	140	NuclAT_0	-	Antitoxin
-	2047183..2047322	+	140	NuclAT_0	-	Antitoxin
-	2047183..2047322	+	140	NuclAT_0	-	Antitoxin
ELZ56_RS10335	2047314..2047490	-	177	WP_011447039.1	putative holin-like toxin	Toxin
ELZ56_RS10340	2047599..2048372	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
ELZ56_RS10350	2048793..2049167	-	375	Protein_1916	hypothetical protein	-
ELZ56_RS10355	2049223..2049510	-	288	WP_001040259.1	hypothetical protein	-
ELZ56_RS10360	2049557..2049709	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL / hld	2037060..2120318	83258

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T286785 WP_011447039.1 NZ_LR134093:c2047490-2047314 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT286785 NZ_LR134093:2047183-2047322 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin