28678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3448079..3448688 Replicon chromosome
Accession NC_019940
Organism Thioflavicoccus mobilis 8321

Toxin (Protein)


Gene name higB Uniprot ID L0H2L3
Locus tag THIMO_RS14955 Protein ID WP_015281957.1
Coordinates 3448353..3448688 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID L0GYH7
Locus tag THIMO_RS14950 Protein ID WP_015281956.1
Coordinates 3448079..3448369 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THIMO_RS14940 3445755..3447182 + 1428 WP_041604618.1 efflux transporter outer membrane subunit -
THIMO_RS14945 3447224..3447853 - 630 Protein_3044 helix-turn-helix transcriptional regulator -
THIMO_RS14950 3448079..3448369 - 291 WP_015281956.1 helix-turn-helix transcriptional regulator Antitoxin
THIMO_RS14955 3448353..3448688 - 336 WP_015281957.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
THIMO_RS20105 3449507..3449671 + 165 WP_015281958.1 hypothetical protein -
THIMO_RS14965 3450327..3452330 - 2004 WP_015281959.1 DNA helicase Rep -
THIMO_RS14970 3452411..3452875 - 465 WP_015281960.1 DUF2269 domain-containing protein -
THIMO_RS14975 3453099..3453326 - 228 WP_015281961.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-90)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12646.81 Da        Isoelectric Point: 10.1078

>T28678 WP_015281957.1 NC_019940:c3448688-3448353 [Thioflavicoccus mobilis 8321]
VPYCIIYYSEAVQTAITSLPDTLAARYIVLTRRMLDFGPNLGEPHTKAFGNGLFELRLKGADGIARVFFCTQVGQRIVML
HCFVKKTNKTPVRERRLAEARMKEIHHADPR

Download         Length: 336 bp

>T28678 NC_019940:c3448688-3448353 [Thioflavicoccus mobilis 8321]
GTGCCCTACTGCATTATCTACTATAGCGAGGCCGTCCAGACGGCGATCACGTCGTTGCCCGACACCCTGGCGGCACGCTA
TATCGTCTTGACTCGGCGCATGCTGGATTTTGGTCCGAATCTGGGCGAGCCACATACCAAGGCATTCGGTAACGGCTTGT
TCGAGCTACGTCTGAAAGGCGCCGATGGGATCGCGCGTGTCTTCTTCTGCACGCAGGTCGGACAGCGGATCGTGATGCTG
CACTGCTTTGTGAAGAAGACCAACAAGACACCCGTGCGCGAACGGCGTCTCGCCGAAGCGCGGATGAAGGAGATCCACCA
TGCAGACCCACGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10700.26 Da        Isoelectric Point: 7.3606

>AT28678 WP_015281956.1 NC_019940:c3448369-3448079 [Thioflavicoccus mobilis 8321]
MQTHDELIETLIQRPGVQAEVERLEREEFGLLDLLLKARHEAGLSQAQVAERMGTHAPAVARLERALATGKHSPSVATLR
KYARACGKNLFVDLRD

Download         Length: 291 bp

>AT28678 NC_019940:c3448369-3448079 [Thioflavicoccus mobilis 8321]
ATGCAGACCCACGATGAACTGATCGAGACGCTGATACAGCGTCCCGGTGTGCAAGCCGAGGTCGAGCGCCTGGAGCGGGA
GGAATTCGGCCTGCTCGACCTGTTACTGAAGGCACGTCACGAGGCGGGGCTTTCCCAGGCTCAGGTCGCCGAGCGCATGG
GGACTCACGCGCCCGCGGTTGCGCGCTTGGAGCGGGCGCTGGCGACGGGCAAGCACTCGCCGTCCGTTGCCACCTTGCGC
AAATATGCTCGCGCTTGCGGCAAGAATCTCTTCGTGGATCTCAGGGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L0H2L3

Antitoxin

Source ID Structure
AlphaFold DB L0GYH7

References