Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1965274..1965776 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL041_RS09365 Protein ID WP_000767829.1
Coordinates 1965522..1965776 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL041_RS09360 Protein ID WP_001259255.1
Coordinates 1965274..1965525 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS09330 1960452..1961519 - 1068 WP_000080134.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL041_RS09335 1961519..1962589 - 1071 WP_000108952.1 histidinol-phosphate transaminase -
EL041_RS09340 1962586..1963890 - 1305 WP_001300646.1 histidinol dehydrogenase -
EL041_RS09345 1963896..1964795 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL041_RS09350 1964941..1964991 - 51 WP_071779509.1 his operon leader peptide -
EL041_RS09360 1965274..1965525 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL041_RS09365 1965522..1965776 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL041_RS09370 1965859..1966683 + 825 WP_000754737.1 SDR family oxidoreductase -
EL041_RS09375 1966729..1967658 + 930 WP_000803351.1 LysR family transcriptional regulator -
EL041_RS09380 1967872..1967934 + 63 WP_010723108.1 membrane protein YoeI -
EL041_RS09385 1967924..1969282 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL041_RS09390 1969461..1970519 + 1059 WP_000492324.1 transport protein YeeE -
EL041_RS09395 1970533..1970760 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T286763 WP_000767829.1 NZ_LR134092:1965522-1965776 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT286763 WP_001259255.1 NZ_LR134092:1965274-1965525 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References