286754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2467885..2468384 Replicon chromosome
Accession NZ_LR134091
Organism Staphylococcus aureus strain NCTC4137

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ELZ58_RS12850 Protein ID WP_000074044.1
Coordinates 2467885..2468127 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag ELZ58_RS12855 Protein ID WP_000587618.1
Coordinates 2468127..2468384 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ58_RS12830 2463190..2464377 - 1188 WP_000026189.1 MFS transporter -
ELZ58_RS12835 2464773..2465549 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
ELZ58_RS12840 2465542..2466204 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
ELZ58_RS12845 2466452..2467528 - 1077 WP_001076672.1 M42 family metallopeptidase -
ELZ58_RS12850 2467885..2468127 - 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
ELZ58_RS12855 2468127..2468384 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ58_RS12865 2468743..2469198 + 456 WP_000732082.1 DUF1307 domain-containing protein -
ELZ58_RS12870 2469366..2470943 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
ELZ58_RS12875 2471138..2471887 + 750 WP_000072459.1 hypothetical protein -
ELZ58_RS12880 2472118..2473311 - 1194 WP_000675411.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T286754 WP_000074044.1 NZ_LR134091:c2468127-2467885 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT286754 WP_000587618.1 NZ_LR134091:c2468384-2468127 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References