Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2409444..2409961 Replicon chromosome
Accession NZ_LR134091
Organism Staphylococcus aureus strain NCTC4137

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ELZ58_RS12530 Protein ID WP_000113262.1
Coordinates 2409444..2409710 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ELZ58_RS12535 Protein ID WP_000584499.1
Coordinates 2409710..2409961 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ58_RS12500 2404863..2405399 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
ELZ58_RS12505 2405633..2406457 - 825 WP_000572040.1 formate/nitrite transporter family protein -
ELZ58_RS12510 2406674..2406856 - 183 WP_000079142.1 hypothetical protein -
ELZ58_RS12515 2406943..2407410 - 468 WP_000153344.1 SRPBCC domain-containing protein -
ELZ58_RS12520 2407596..2409149 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ELZ58_RS12525 2409338..2409409 - 72 Protein_2309 hypothetical protein -
ELZ58_RS12530 2409444..2409710 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ELZ58_RS12535 2409710..2409961 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ58_RS12540 2410126..2410227 - 102 WP_031774922.1 hypothetical protein -
ELZ58_RS12545 2410234..2410833 - 600 WP_000162813.1 DsbA family protein -
ELZ58_RS12550 2410852..2411214 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ELZ58_RS12555 2411469..2412719 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
ELZ58_RS12560 2412798..2414117 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2412798..2414117 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286752 WP_000113262.1 NZ_LR134091:c2409710-2409444 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286752 WP_000584499.1 NZ_LR134091:c2409961-2409710 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References