Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2566743..2567266 Replicon chromosome
Accession NZ_LR134090
Organism Staphylococcus aureus strain NCTC9555

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag ELZ60_RS13460 Protein ID WP_000074048.1
Coordinates 2566743..2567009 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag ELZ60_RS13465 Protein ID WP_000587617.1
Coordinates 2567009..2567266 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ60_RS13440 2561953..2563140 - 1188 WP_000026189.1 MFS transporter -
ELZ60_RS13445 2563535..2564311 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
ELZ60_RS13450 2564304..2564966 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
ELZ60_RS13455 2565311..2566387 - 1077 WP_001076674.1 M42 family metallopeptidase -
ELZ60_RS13460 2566743..2567009 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
ELZ60_RS13465 2567009..2567266 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ60_RS13475 2567627..2568082 + 456 WP_000732082.1 DUF1307 domain-containing protein -
ELZ60_RS13480 2568250..2569827 - 1578 WP_126509096.1 FMN-binding glutamate synthase family protein -
ELZ60_RS13485 2570021..2570770 + 750 WP_000072455.1 CPBP family intramembrane metalloprotease -
ELZ60_RS13490 2570994..2572187 - 1194 WP_000675398.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286744 WP_000074048.1 NZ_LR134090:c2567009-2566743 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT286744 WP_000587617.1 NZ_LR134090:c2567266-2567009 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References