Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2509910..2510427 Replicon chromosome
Accession NZ_LR134090
Organism Staphylococcus aureus strain NCTC9555

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ELZ60_RS13170 Protein ID WP_000375483.1
Coordinates 2509910..2510176 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ELZ60_RS13175 Protein ID WP_000584499.1
Coordinates 2510176..2510427 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ60_RS13140 2505061..2505597 - 537 WP_126509093.1 GNAT family N-acetyltransferase -
ELZ60_RS13150 2506117..2506941 - 825 WP_000594631.1 formate/nitrite transporter family protein -
ELZ60_RS13155 2507144..2507326 - 183 WP_000079140.1 hypothetical protein -
ELZ60_RS13160 2507413..2507880 - 468 WP_000153340.1 SRPBCC domain-containing protein -
ELZ60_RS13165 2508066..2509616 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ELZ60_RS13170 2509910..2510176 - 267 WP_000375483.1 Txe/YoeB family addiction module toxin Toxin
ELZ60_RS13175 2510176..2510427 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ60_RS13180 2510591..2510691 - 101 Protein_2433 hypothetical protein -
ELZ60_RS13185 2510698..2511297 - 600 WP_000162810.1 DsbA family protein -
ELZ60_RS13190 2511316..2511678 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ELZ60_RS13195 2511933..2513183 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
ELZ60_RS13200 2513276..2514007 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
ELZ60_RS13205 2514004..2514723 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10450.05 Da        Isoelectric Point: 10.2538

>T286743 WP_000375483.1 NZ_LR134090:c2510176-2509910 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286743 WP_000584499.1 NZ_LR134090:c2510427-2510176 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References