Detailed information of TA system TA286733

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 358145..358663
• Replicon: chromosome
• Accession: NZ_LR134090
• Organism: Staphylococcus aureus strain NCTC9555

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: ELZ60_RS01770
• Protein ID: WP_000448764.1
• Coordinates: 358361..358663 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	358145..358281 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELZ60_RS01730	353239..353529	+	291	WP_000179860.1	hypothetical protein	-
ELZ60_RS01735	353545..355455	+	1911	WP_000429563.1	hypothetical protein	-
ELZ60_RS01740	355455..356921	+	1467	WP_000067157.1	BppU family phage baseplate upper protein	-
ELZ60_RS01745	356921..357310	+	390	WP_001166604.1	DUF2977 domain-containing protein	-
ELZ60_RS01750	357303..357467	+	165	WP_000916020.1	XkdX family protein	-
ELZ60_RS01755	357513..357812	+	300	WP_000466773.1	DUF2951 family protein	-
ELZ60_RS14885	357964..358153	+	190	Protein_333	putative holin-like toxin	-
-	358145..358281	-	137	NuclAT_0	-	Antitoxin
-	358145..358281	-	137	NuclAT_0	-	Antitoxin
-	358145..358281	-	137	NuclAT_0	-	Antitoxin
-	358145..358281	-	137	NuclAT_0	-	Antitoxin
ELZ60_RS01765	358200..358310	-	111	WP_070003492.1	hypothetical protein	-
ELZ60_RS01770	358361..358663	+	303	WP_000448764.1	phage holin	Toxin
ELZ60_RS01775	358675..360129	+	1455	WP_000930278.1	N-acetylmuramoyl-L-alanine amidase	-
ELZ60_RS01785	361643..362140	+	498	WP_001803960.1	hypothetical protein	-
ELZ60_RS01795	362700..363527	-	828	WP_000136028.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	317350..360129	42779
	-	inside	Prophage	-	geh	312793..360129	47336

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11230.99 Da
• Isoelectric Point: 9.6587

>T286733 WP_000448764.1 NZ_LR134090:358361-358663 [Staphylococcus aureus]
METKVITRYIVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTAYKDNPTSQEGRWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

Antitoxin

Nucleotide

• Length: 137 bp

>AT286733 NZ_LR134090:c358281-358145 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTGTAGTTAAAT
GAATTTATATAATCCTCTAACCATCGTACTCGTCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin