Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2492815..2493332 Replicon chromosome
Accession NZ_LR134087
Organism Staphylococcus aureus strain NCTC7121

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ELZ50_RS13035 Protein ID WP_000113262.1
Coordinates 2492815..2493081 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ELZ50_RS13040 Protein ID WP_000584499.1
Coordinates 2493081..2493332 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ50_RS13010 2488233..2488769 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
ELZ50_RS13015 2489003..2489827 - 825 WP_000572040.1 formate/nitrite transporter family protein -
ELZ50_RS13020 2490044..2490226 - 183 WP_000079142.1 hypothetical protein -
ELZ50_RS13025 2490313..2490780 - 468 WP_001836792.1 SRPBCC domain-containing protein -
ELZ50_RS13030 2490966..2492519 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ELZ50_RS13035 2492815..2493081 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ELZ50_RS13040 2493081..2493332 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ50_RS13045 2493497..2493598 - 102 WP_031774922.1 hypothetical protein -
ELZ50_RS13050 2493605..2494204 - 600 WP_000162813.1 DsbA family protein -
ELZ50_RS13055 2494223..2494585 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ELZ50_RS13060 2494840..2496090 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
ELZ50_RS13065 2496169..2497488 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2496169..2497488 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286725 WP_000113262.1 NZ_LR134087:c2493081-2492815 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286725 WP_000584499.1 NZ_LR134087:c2493332-2493081 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References