Detailed information of TA system TA286720

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2047899..2048198
• Replicon: chromosome
• Accession: NZ_LR134087
• Organism: Staphylococcus aureus strain NCTC7121

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: ELZ50_RS10525
• Protein ID: WP_072353918.1
• Coordinates: 2048022..2048198 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2047899..2047954 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELZ50_RS10470	2043457..2043636	+	180	WP_000669789.1	hypothetical protein	-
ELZ50_RS10480	2043947..2044207	+	261	WP_001791826.1	hypothetical protein	-
ELZ50_RS10485	2044260..2044610	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
ELZ50_RS10490	2045120..2045455	-	336	Protein_1941	SH3 domain-containing protein	-
ELZ50_RS10505	2046107..2046598	-	492	WP_000920041.1	staphylokinase	-
ELZ50_RS10510	2046789..2047544	-	756	WP_000861038.1	CHAP domain-containing protein	-
ELZ50_RS10515	2047556..2047810	-	255	WP_000611512.1	phage holin	-
ELZ50_RS10520	2047862..2047969	+	108	WP_001791821.1	hypothetical protein	-
-	2047891..2048030	+	140	NuclAT_0	-	-
-	2047891..2048030	+	140	NuclAT_0	-	-
-	2047891..2048030	+	140	NuclAT_0	-	-
-	2047891..2048030	+	140	NuclAT_0	-	-
-	2047899..2047954	+	56	-	-	Antitoxin
ELZ50_RS10525	2048022..2048198	-	177	WP_072353918.1	putative holin-like toxin	Toxin
ELZ50_RS10530	2048341..2048715	-	375	WP_000340977.1	hypothetical protein	-
ELZ50_RS10535	2048771..2049058	-	288	WP_001262620.1	hypothetical protein	-
ELZ50_RS10540	2049104..2049256	-	153	WP_001000058.1	hypothetical protein	-
ELZ50_RS10545	2049249..2053031	-	3783	WP_001836550.1	phage protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2044260..2112792	68532

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T286720 WP_072353918.1 NZ_LR134087:c2048198-2048022 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT286720 NZ_LR134087:2047899-2047954 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin