286717

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2557152..2557675 Replicon chromosome
Accession NZ_LR134086
Organism Staphylococcus aureus strain NCTC13142

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag ELZ49_RS13250 Protein ID WP_000074048.1
Coordinates 2557152..2557418 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag ELZ49_RS13255 Protein ID WP_000587616.1
Coordinates 2557418..2557675 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ49_RS13230 2552363..2553550 - 1188 WP_000026196.1 MFS transporter -
ELZ49_RS13235 2553944..2554720 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
ELZ49_RS13240 2554713..2555375 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
ELZ49_RS13245 2555721..2556797 - 1077 WP_001076688.1 M42 family metallopeptidase -
ELZ49_RS13250 2557152..2557418 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
ELZ49_RS13255 2557418..2557675 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ49_RS13265 2558034..2558489 + 456 WP_000732088.1 DUF1307 domain-containing protein -
ELZ49_RS13270 2558657..2560234 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
ELZ49_RS13275 2560429..2561178 + 750 WP_000072439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286717 WP_000074048.1 NZ_LR134086:c2557418-2557152 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286717 WP_000587616.1 NZ_LR134086:c2557675-2557418 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References