286715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2499145..2499662 Replicon chromosome
Accession NZ_LR134086
Organism Staphylococcus aureus strain NCTC13142

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ELZ49_RS12945 Protein ID WP_000113261.1
Coordinates 2499145..2499411 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ELZ49_RS12950 Protein ID WP_000584499.1
Coordinates 2499411..2499662 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ49_RS12920 2494582..2495118 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
ELZ49_RS12925 2495352..2496176 - 825 WP_000594637.1 formate/nitrite transporter family protein -
ELZ49_RS12930 2496379..2496561 - 183 WP_000250735.1 hypothetical protein -
ELZ49_RS12935 2496648..2497115 - 468 WP_000153345.1 SRPBCC domain-containing protein -
ELZ49_RS12940 2497301..2498851 - 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ELZ49_RS12945 2499145..2499411 - 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
ELZ49_RS12950 2499411..2499662 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ49_RS12955 2499825..2499926 - 102 Protein_2414 hypothetical protein -
ELZ49_RS12960 2499933..2500532 - 600 WP_000162810.1 DsbA family protein -
ELZ49_RS12965 2500551..2500913 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ELZ49_RS12970 2501168..2502418 + 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
ELZ49_RS12975 2502503..2503234 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
ELZ49_RS12980 2503231..2503950 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T286715 WP_000113261.1 NZ_LR134086:c2499411-2499145 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286715 WP_000584499.1 NZ_LR134086:c2499662-2499411 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References